Patent
US 10,814,021PARAMAGNETIC BORON-DOPED GRAPHENE QUANTUM DOTS AND THEIR APPLICATION FOR SAFE MAGNETIC RESONANCE IMAGING
Miqin Zhang
US
Copyright © 2026 Matter42. All rights reserved.
Patent
Atlas literature
Patent
US 10,814,021Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of obtaining a T- weighted magnetic resonance image of a tissue, comprising: (a) administering an effective dose of a contrast agent to a subject h aving a tissue to be imaged, wh erein the contrast agent is a boron-doped graphene quantum dot; and (b) subjecting the subject to magnetic resonance imaging to provide a TI- weighted magnetic resonance image of the subject's tissue. Original
The method of Claim 1, wherein the tissue is heart, lung, liver, kidney, stomach, spleen, or brain tissue. Original
The method of Claim 1, wherein the tissue is m uscle tissue or vascular tissue. Original
The method of Claim 1, wherein the contrast agent is administered intravenously or subcutaneously. Original
The method of Claim 1, wherein the contrast agent is administered as a pharmaceutically acceptable composi tion, Original
The method of Claim 1, wherein the boron-doped graphene quantum dot has a r a tio of transverse relaxivity (r2) to longitudinal relaxivity (ri) from about I to about 5 at a magnetic fi eld strength of from about 3 to about 14 T. Original
8. The method of Claim 1, wherein the boron-doped graphene quantum dot comprises graphene having from one to four graphene layers. Original
(O riginal) The method of Claim 1, wherein the bo r on-doped g r aphene quantum dot comp ri ses from about 2 to about 8 % boron atoms based on total numbe r of carbon, oxygen, and bo r on atoms in the g r aphene qua ntum dot as measured by X-ray photo el ect r on spectroscopy (XP S). Original
The method of Claim 1, w herein the boron-doped graphene quantum dot is substantially metal free. Original
12. (Withdra w n) The graphene quantum d o t of Claim 1 1 ha v ing longitudinal relaxivity (ri) from about 5 to about 20 mM-s- at a magnetic fi eld strength of 14 T. Withdrawn
The method of Clai m 1, wherein the effective amount of contrast agent is from about 5 to about 50 m g/kg subject. Original
A graphene quantum dot, comprising a graphene quantum dot having vacancy defects, wherein at least a portion of the vacancy defects are occupied by boron atoms, wherein t h e graphene quant u m dot h as a ratio of transve r se r elaxivity (r 2) to longitudinal relaxi v ity (ri) from about I to about 5 at a magnetic field strength of from about 3 to about 14 T. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantu m dot compr is es g r aphene having from one to four graphene l ayer s. Withdrawn
(Withdr a wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises a multila y er graphene having from four graphene layers. Withdrawn
(W ithdra wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises graphene having a single graphene layer. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantum dot is substantially metal free. Withdrawn
The graphene quantum d ot of Claim 11 having a magnetization v alue from about 0. 1 to about 4 emu/g at 6K and from about 0.01 to about 0. 05 emu/g at 3 00K. Withdrawn
1 9. (W ithdra w n) The graphene qua ntum d ot of Claim 11 having a serum h al f-life from about 1 to about 5 hours. Withdrawn
The graphene quantum d ot of Clai m i1, comprising fro m about 2 to about 8 % boron atoms based on total number of carbon, oxygen, and boron atoms in the graphene quantum d ot as measured by X-ray p hotoelectron spectroscop y (XPS). Withdrawn
2 0. A method for preparing boron-doped graphene quantum dots, corn pri s ing: (a) adding hydrogen peroxide to a solution of 4-vinylphenylboronic acid and a boron source in an organic solvent to provide a precursor solution; and (b) heating the precursor solution at an elevated temperature for a pre-determined time to provide boron-doped graphene quantum dots. Withdrawn
Materials described outside the worked examples.
boron-doped graphene quantum dot
4-vinylphenylboronic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
r2/r1 ratio | — | boron-doped graphene quantum dot |
longitudinal relaxivity r1 | — |
Patent
Atlas literature
Patent
US 10,814,021Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of obtaining a T- weighted magnetic resonance image of a tissue, comprising: (a) administering an effective dose of a contrast agent to a subject h aving a tissue to be imaged, wh erein the contrast agent is a boron-doped graphene quantum dot; and (b) subjecting the subject to magnetic resonance imaging to provide a TI- weighted magnetic resonance image of the subject's tissue. Original
The method of Claim 1, wherein the tissue is heart, lung, liver, kidney, stomach, spleen, or brain tissue. Original
The method of Claim 1, wherein the tissue is m uscle tissue or vascular tissue. Original
The method of Claim 1, wherein the contrast agent is administered intravenously or subcutaneously. Original
The method of Claim 1, wherein the contrast agent is administered as a pharmaceutically acceptable composi tion, Original
The method of Claim 1, wherein the boron-doped graphene quantum dot has a r a tio of transverse relaxivity (r2) to longitudinal relaxivity (ri) from about I to about 5 at a magnetic fi eld strength of from about 3 to about 14 T. Original
8. The method of Claim 1, wherein the boron-doped graphene quantum dot comprises graphene having from one to four graphene layers. Original
(O riginal) The method of Claim 1, wherein the bo r on-doped g r aphene quantum dot comp ri ses from about 2 to about 8 % boron atoms based on total numbe r of carbon, oxygen, and bo r on atoms in the g r aphene qua ntum dot as measured by X-ray photo el ect r on spectroscopy (XP S). Original
The method of Claim 1, w herein the boron-doped graphene quantum dot is substantially metal free. Original
12. (Withdra w n) The graphene quantum d o t of Claim 1 1 ha v ing longitudinal relaxivity (ri) from about 5 to about 20 mM-s- at a magnetic fi eld strength of 14 T. Withdrawn
The method of Clai m 1, wherein the effective amount of contrast agent is from about 5 to about 50 m g/kg subject. Original
A graphene quantum dot, comprising a graphene quantum dot having vacancy defects, wherein at least a portion of the vacancy defects are occupied by boron atoms, wherein t h e graphene quant u m dot h as a ratio of transve r se r elaxivity (r 2) to longitudinal relaxi v ity (ri) from about I to about 5 at a magnetic field strength of from about 3 to about 14 T. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantu m dot compr is es g r aphene having from one to four graphene l ayer s. Withdrawn
(Withdr a wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises a multila y er graphene having from four graphene layers. Withdrawn
(W ithdra wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises graphene having a single graphene layer. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantum dot is substantially metal free. Withdrawn
The graphene quantum d ot of Claim 11 having a magnetization v alue from about 0. 1 to about 4 emu/g at 6K and from about 0.01 to about 0. 05 emu/g at 3 00K. Withdrawn
1 9. (W ithdra w n) The graphene qua ntum d ot of Claim 11 having a serum h al f-life from about 1 to about 5 hours. Withdrawn
The graphene quantum d ot of Clai m i1, comprising fro m about 2 to about 8 % boron atoms based on total number of carbon, oxygen, and boron atoms in the graphene quantum d ot as measured by X-ray p hotoelectron spectroscop y (XPS). Withdrawn
2 0. A method for preparing boron-doped graphene quantum dots, corn pri s ing: (a) adding hydrogen peroxide to a solution of 4-vinylphenylboronic acid and a boron source in an organic solvent to provide a precursor solution; and (b) heating the precursor solution at an elevated temperature for a pre-determined time to provide boron-doped graphene quantum dots. Withdrawn
Materials described outside the worked examples.
boron-doped graphene quantum dot
4-vinylphenylboronic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
r2/r1 ratio | — | boron-doped graphene quantum dot |
longitudinal relaxivity r1 | — |
Patent
Atlas literature
Patent
US 10,814,021Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of obtaining a T- weighted magnetic resonance image of a tissue, comprising: (a) administering an effective dose of a contrast agent to a subject h aving a tissue to be imaged, wh erein the contrast agent is a boron-doped graphene quantum dot; and (b) subjecting the subject to magnetic resonance imaging to provide a TI- weighted magnetic resonance image of the subject's tissue. Original
The method of Claim 1, wherein the tissue is heart, lung, liver, kidney, stomach, spleen, or brain tissue. Original
The method of Claim 1, wherein the tissue is m uscle tissue or vascular tissue. Original
The method of Claim 1, wherein the contrast agent is administered intravenously or subcutaneously. Original
The method of Claim 1, wherein the contrast agent is administered as a pharmaceutically acceptable composi tion, Original
The method of Claim 1, wherein the boron-doped graphene quantum dot has a r a tio of transverse relaxivity (r2) to longitudinal relaxivity (ri) from about I to about 5 at a magnetic fi eld strength of from about 3 to about 14 T. Original
8. The method of Claim 1, wherein the boron-doped graphene quantum dot comprises graphene having from one to four graphene layers. Original
(O riginal) The method of Claim 1, wherein the bo r on-doped g r aphene quantum dot comp ri ses from about 2 to about 8 % boron atoms based on total numbe r of carbon, oxygen, and bo r on atoms in the g r aphene qua ntum dot as measured by X-ray photo el ect r on spectroscopy (XP S). Original
The method of Claim 1, w herein the boron-doped graphene quantum dot is substantially metal free. Original
12. (Withdra w n) The graphene quantum d o t of Claim 1 1 ha v ing longitudinal relaxivity (ri) from about 5 to about 20 mM-s- at a magnetic fi eld strength of 14 T. Withdrawn
The method of Clai m 1, wherein the effective amount of contrast agent is from about 5 to about 50 m g/kg subject. Original
A graphene quantum dot, comprising a graphene quantum dot having vacancy defects, wherein at least a portion of the vacancy defects are occupied by boron atoms, wherein t h e graphene quant u m dot h as a ratio of transve r se r elaxivity (r 2) to longitudinal relaxi v ity (ri) from about I to about 5 at a magnetic field strength of from about 3 to about 14 T. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantu m dot compr is es g r aphene having from one to four graphene l ayer s. Withdrawn
(Withdr a wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises a multila y er graphene having from four graphene layers. Withdrawn
(W ithdra wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises graphene having a single graphene layer. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantum dot is substantially metal free. Withdrawn
The graphene quantum d ot of Claim 11 having a magnetization v alue from about 0. 1 to about 4 emu/g at 6K and from about 0.01 to about 0. 05 emu/g at 3 00K. Withdrawn
1 9. (W ithdra w n) The graphene qua ntum d ot of Claim 11 having a serum h al f-life from about 1 to about 5 hours. Withdrawn
The graphene quantum d ot of Clai m i1, comprising fro m about 2 to about 8 % boron atoms based on total number of carbon, oxygen, and boron atoms in the graphene quantum d ot as measured by X-ray p hotoelectron spectroscop y (XPS). Withdrawn
2 0. A method for preparing boron-doped graphene quantum dots, corn pri s ing: (a) adding hydrogen peroxide to a solution of 4-vinylphenylboronic acid and a boron source in an organic solvent to provide a precursor solution; and (b) heating the precursor solution at an elevated temperature for a pre-determined time to provide boron-doped graphene quantum dots. Withdrawn
Materials described outside the worked examples.
boron-doped graphene quantum dot
4-vinylphenylboronic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
r2/r1 ratio | — | boron-doped graphene quantum dot |
longitudinal relaxivity r1 | — |
Patent
Atlas literature
Patent
US 10,814,021Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
A method of obtaining a T- weighted magnetic resonance image of a tissue, comprising: (a) administering an effective dose of a contrast agent to a subject h aving a tissue to be imaged, wh erein the contrast agent is a boron-doped graphene quantum dot; and (b) subjecting the subject to magnetic resonance imaging to provide a TI- weighted magnetic resonance image of the subject's tissue. Original
The method of Claim 1, wherein the tissue is heart, lung, liver, kidney, stomach, spleen, or brain tissue. Original
The method of Claim 1, wherein the tissue is m uscle tissue or vascular tissue. Original
The method of Claim 1, wherein the contrast agent is administered intravenously or subcutaneously. Original
The method of Claim 1, wherein the contrast agent is administered as a pharmaceutically acceptable composi tion, Original
The method of Claim 1, wherein the boron-doped graphene quantum dot has a r a tio of transverse relaxivity (r2) to longitudinal relaxivity (ri) from about I to about 5 at a magnetic fi eld strength of from about 3 to about 14 T. Original
8. The method of Claim 1, wherein the boron-doped graphene quantum dot comprises graphene having from one to four graphene layers. Original
(O riginal) The method of Claim 1, wherein the bo r on-doped g r aphene quantum dot comp ri ses from about 2 to about 8 % boron atoms based on total numbe r of carbon, oxygen, and bo r on atoms in the g r aphene qua ntum dot as measured by X-ray photo el ect r on spectroscopy (XP S). Original
The method of Claim 1, w herein the boron-doped graphene quantum dot is substantially metal free. Original
12. (Withdra w n) The graphene quantum d o t of Claim 1 1 ha v ing longitudinal relaxivity (ri) from about 5 to about 20 mM-s- at a magnetic fi eld strength of 14 T. Withdrawn
The method of Clai m 1, wherein the effective amount of contrast agent is from about 5 to about 50 m g/kg subject. Original
A graphene quantum dot, comprising a graphene quantum dot having vacancy defects, wherein at least a portion of the vacancy defects are occupied by boron atoms, wherein t h e graphene quant u m dot h as a ratio of transve r se r elaxivity (r 2) to longitudinal relaxi v ity (ri) from about I to about 5 at a magnetic field strength of from about 3 to about 14 T. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantu m dot compr is es g r aphene having from one to four graphene l ayer s. Withdrawn
(Withdr a wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises a multila y er graphene having from four graphene layers. Withdrawn
(W ithdra wn) The graphene quantum dot of Claim 11, wherein the graphene quantum dot comprises graphene having a single graphene layer. Withdrawn
The graphene quantum dot of Claim 11, wherein the graphene quantum dot is substantially metal free. Withdrawn
The graphene quantum d ot of Claim 11 having a magnetization v alue from about 0. 1 to about 4 emu/g at 6K and from about 0.01 to about 0. 05 emu/g at 3 00K. Withdrawn
1 9. (W ithdra w n) The graphene qua ntum d ot of Claim 11 having a serum h al f-life from about 1 to about 5 hours. Withdrawn
The graphene quantum d ot of Clai m i1, comprising fro m about 2 to about 8 % boron atoms based on total number of carbon, oxygen, and boron atoms in the graphene quantum d ot as measured by X-ray p hotoelectron spectroscop y (XPS). Withdrawn
2 0. A method for preparing boron-doped graphene quantum dots, corn pri s ing: (a) adding hydrogen peroxide to a solution of 4-vinylphenylboronic acid and a boron source in an organic solvent to provide a precursor solution; and (b) heating the precursor solution at an elevated temperature for a pre-determined time to provide boron-doped graphene quantum dots. Withdrawn
Materials described outside the worked examples.
boron-doped graphene quantum dot
4-vinylphenylboronic acid
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
r2/r1 ratio | — | boron-doped graphene quantum dot |
longitudinal relaxivity r1 | — |
hydrogen peroxide
H₂O₂
magnetization at 6K | — | boron-doped graphene quantum dot |
magnetization at 300K | — | boron-doped graphene quantum dot |
serum half-life | — | boron-doped graphene quantum dot |
boron atom content by XPS | — | boron-doped graphene quantum dot |
Duration | 1–5 hours | — |
Thickness | 3–8 nm | — |
Duration | 18–36 hours | — |
Thickness | 5–20 mM | — |
hydrogen peroxide
H₂O₂
magnetization at 6K | — | boron-doped graphene quantum dot |
magnetization at 300K | — | boron-doped graphene quantum dot |
serum half-life | — | boron-doped graphene quantum dot |
boron atom content by XPS | — | boron-doped graphene quantum dot |
Duration | 1–5 hours | — |
Thickness | 3–8 nm | — |
Duration | 18–36 hours | — |
Thickness | 5–20 mM | — |
hydrogen peroxide
H₂O₂
magnetization at 6K | — | boron-doped graphene quantum dot |
magnetization at 300K | — | boron-doped graphene quantum dot |
serum half-life | — | boron-doped graphene quantum dot |
boron atom content by XPS | — | boron-doped graphene quantum dot |
Duration | 1–5 hours | — |
Thickness | 3–8 nm | — |
Duration | 18–36 hours | — |
Thickness | 5–20 mM | — |
hydrogen peroxide
H₂O₂
magnetization at 6K | — | boron-doped graphene quantum dot |
magnetization at 300K | — | boron-doped graphene quantum dot |
serum half-life | — | boron-doped graphene quantum dot |
boron atom content by XPS | — | boron-doped graphene quantum dot |
Duration | 1–5 hours | — |
Thickness | 3–8 nm | — |
Duration | 18–36 hours | — |
Thickness | 5–20 mM | — |