Patent
US 10,918,856GRAPHENE BIO-DEVICE FOR ELECTROTHERAPY
Sunggu Yang
US
Copyright © 2026 Matter42. All rights reserved.
Patent
Atlas literature
Patent
US 10,918,856Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 depicts flexible graphene electrode array and treatment of epilepsy, (a) an schematic diagram of a graphene-based seizure sensor (b) an optical image of …
FIG. 2 depicts characteristics of graphene electr o des (a) E IS of doped 1-, 2-, and 4-layer graphene electr o des and a Au electr o de f o r a 1 x 1 cm 2 a r …
FIG. 3 depicts in vitro multichannel recording of neuronal activities using graphene electronics (a) A thalamocortical slice on the graphene-based multichannel …
FIG. 4 depicts in viv o multichannel re co rding and stimulation of neuronal activities using graphene electronics. (a) a schematic diagram of a recording and …
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-8. Canceled
Canceled
A neurostimulating apparatus, consisting of: a graphene bio-device consisting of: a flexible substrate which is PM M A(polymethyl methacrylate); doped four-layer graphene electrodes on the flexible substrat, forming an electrode array having 30 channels for recording and electrotherapy; and an insulation layer on the doped four-layer graphene electrodes, which comprise ground electrodes, reference electrodes, recording electrodes and stimulation electrodes; a neurostimulator generating sinusoidal high frequency stimulation signals and enabling the graphen bio-device to provide neurostimulating signals to a target, wherein the sinusoidal high frequency stimulation signals include an amplitude of 1V, a frequency of 100 Hz, and a duration of 30 sec; an amplifier intensifying brain signals from the graphene bio-device; and an interface transmitting the amplified brain signals to a user terminal, wherein the graphene bio-device, the neurostimulator, the amplifier, and the interface are connected to each other by a lead. Currently amended
The neurostimulating apparatus of claim 9, wherein the insulation layer is OCR(optical clean resin), OCA(optical clean adhesive) or SU-8. Previously presented
The neurostimulating apparatus of claim 9, wherein the doped four-layer graphene electrodes have a specific capacitance of 326.7 F/g. Currently amended
The neurostimulating apparatus of claim 9, wherein the graphene bio-device is placed in somatosensory area or motor cortical area. Previously presented
A method for detecting signals from a mammalian brain or a mammalian tissue and electrical stimulation to the brain or the tissue using [[a]] the graphene SVG 16030863.12-23-2020.KJ₇KFP₂XLDFLYX3.CLM.1.svg 0.16 1.61 Black and white Currently amended
The method of claim 10, wherein the electrical stimulation is sinusoidal high frequency stimulation(s H FS). Original
12-13. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
4 materials2 process steps
Monolayer graphene was grown on 25 µm thick Cu foil by CVD at 1000°C under atmospheric pressure using a CH₄/H₂/He gas mixture. Multilayer graphene electrodes were formed by repeated PMMA-supported transfer and Cu etching in ammonium persulfate solution. The transferred graphene was patterned by photolithography and oxygen plasma etching, and chemically doped with nitric acid vapour. The electrode array was mounted onto mouse brain cortex for electrotherapy and neural recording experiments.
No measurements recorded
C₅₇BL/6 mice were anaesthetized and brain slices (400 µm) containing somatosensory cortex and thalamus were prepared. Bicuculline (1 mM) was focally injected to induce ictal-like and interictal-like spontaneous activity.
No measurements recorded
Halothane-anaesthetized mice underwent craniotomy exposing a 5×5 mm² cortical region. CSF was drained and graphene electrodes were introduced transdurally for neurophysiological recording.
1 material
Brain signals from graphene-based electronics were processed using a multichannel neural amplifier and acquisition system (Intan Technologies). Stimulations were provided by NI-9263 stimulators (National Instruments). Data were analyzed offline using Matlab.
Layer stacks claimed or described, ordered top of device to substrate.
graphene bio-device (flexible electrode array)
Materials described outside the worked examples.
insulation layer (OCR, OCA, or SU-8)
gold electrode
Au
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
specific capacitance of doped four-layer graphene electrode | 326.7 F/g | doped four-layer graphene |
specific capacitance of gold electrode (comparison) |
Table 1
2b and Table 1&2).
p. 9
Table 2
SVG
SVG 16030863.
p. 9
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,918,856Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 depicts flexible graphene electrode array and treatment of epilepsy, (a) an schematic diagram of a graphene-based seizure sensor (b) an optical image of …
FIG. 2 depicts characteristics of graphene electr o des (a) E IS of doped 1-, 2-, and 4-layer graphene electr o des and a Au electr o de f o r a 1 x 1 cm 2 a r …
FIG. 3 depicts in vitro multichannel recording of neuronal activities using graphene electronics (a) A thalamocortical slice on the graphene-based multichannel …
FIG. 4 depicts in viv o multichannel re co rding and stimulation of neuronal activities using graphene electronics. (a) a schematic diagram of a recording and …
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-8. Canceled
Canceled
A neurostimulating apparatus, consisting of: a graphene bio-device consisting of: a flexible substrate which is PM M A(polymethyl methacrylate); doped four-layer graphene electrodes on the flexible substrat, forming an electrode array having 30 channels for recording and electrotherapy; and an insulation layer on the doped four-layer graphene electrodes, which comprise ground electrodes, reference electrodes, recording electrodes and stimulation electrodes; a neurostimulator generating sinusoidal high frequency stimulation signals and enabling the graphen bio-device to provide neurostimulating signals to a target, wherein the sinusoidal high frequency stimulation signals include an amplitude of 1V, a frequency of 100 Hz, and a duration of 30 sec; an amplifier intensifying brain signals from the graphene bio-device; and an interface transmitting the amplified brain signals to a user terminal, wherein the graphene bio-device, the neurostimulator, the amplifier, and the interface are connected to each other by a lead. Currently amended
The neurostimulating apparatus of claim 9, wherein the insulation layer is OCR(optical clean resin), OCA(optical clean adhesive) or SU-8. Previously presented
The neurostimulating apparatus of claim 9, wherein the doped four-layer graphene electrodes have a specific capacitance of 326.7 F/g. Currently amended
The neurostimulating apparatus of claim 9, wherein the graphene bio-device is placed in somatosensory area or motor cortical area. Previously presented
A method for detecting signals from a mammalian brain or a mammalian tissue and electrical stimulation to the brain or the tissue using [[a]] the graphene SVG 16030863.12-23-2020.KJ₇KFP₂XLDFLYX3.CLM.1.svg 0.16 1.61 Black and white Currently amended
The method of claim 10, wherein the electrical stimulation is sinusoidal high frequency stimulation(s H FS). Original
12-13. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
4 materials2 process steps
Monolayer graphene was grown on 25 µm thick Cu foil by CVD at 1000°C under atmospheric pressure using a CH₄/H₂/He gas mixture. Multilayer graphene electrodes were formed by repeated PMMA-supported transfer and Cu etching in ammonium persulfate solution. The transferred graphene was patterned by photolithography and oxygen plasma etching, and chemically doped with nitric acid vapour. The electrode array was mounted onto mouse brain cortex for electrotherapy and neural recording experiments.
No measurements recorded
C₅₇BL/6 mice were anaesthetized and brain slices (400 µm) containing somatosensory cortex and thalamus were prepared. Bicuculline (1 mM) was focally injected to induce ictal-like and interictal-like spontaneous activity.
No measurements recorded
Halothane-anaesthetized mice underwent craniotomy exposing a 5×5 mm² cortical region. CSF was drained and graphene electrodes were introduced transdurally for neurophysiological recording.
1 material
Brain signals from graphene-based electronics were processed using a multichannel neural amplifier and acquisition system (Intan Technologies). Stimulations were provided by NI-9263 stimulators (National Instruments). Data were analyzed offline using Matlab.
Layer stacks claimed or described, ordered top of device to substrate.
graphene bio-device (flexible electrode array)
Materials described outside the worked examples.
insulation layer (OCR, OCA, or SU-8)
gold electrode
Au
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
specific capacitance of doped four-layer graphene electrode | 326.7 F/g | doped four-layer graphene |
specific capacitance of gold electrode (comparison) |
Table 1
2b and Table 1&2).
p. 9
Table 2
SVG
SVG 16030863.
p. 9
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,918,856Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 depicts flexible graphene electrode array and treatment of epilepsy, (a) an schematic diagram of a graphene-based seizure sensor (b) an optical image of …
FIG. 2 depicts characteristics of graphene electr o des (a) E IS of doped 1-, 2-, and 4-layer graphene electr o des and a Au electr o de f o r a 1 x 1 cm 2 a r …
FIG. 3 depicts in vitro multichannel recording of neuronal activities using graphene electronics (a) A thalamocortical slice on the graphene-based multichannel …
FIG. 4 depicts in viv o multichannel re co rding and stimulation of neuronal activities using graphene electronics. (a) a schematic diagram of a recording and …
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-8. Canceled
Canceled
A neurostimulating apparatus, consisting of: a graphene bio-device consisting of: a flexible substrate which is PM M A(polymethyl methacrylate); doped four-layer graphene electrodes on the flexible substrat, forming an electrode array having 30 channels for recording and electrotherapy; and an insulation layer on the doped four-layer graphene electrodes, which comprise ground electrodes, reference electrodes, recording electrodes and stimulation electrodes; a neurostimulator generating sinusoidal high frequency stimulation signals and enabling the graphen bio-device to provide neurostimulating signals to a target, wherein the sinusoidal high frequency stimulation signals include an amplitude of 1V, a frequency of 100 Hz, and a duration of 30 sec; an amplifier intensifying brain signals from the graphene bio-device; and an interface transmitting the amplified brain signals to a user terminal, wherein the graphene bio-device, the neurostimulator, the amplifier, and the interface are connected to each other by a lead. Currently amended
The neurostimulating apparatus of claim 9, wherein the insulation layer is OCR(optical clean resin), OCA(optical clean adhesive) or SU-8. Previously presented
The neurostimulating apparatus of claim 9, wherein the doped four-layer graphene electrodes have a specific capacitance of 326.7 F/g. Currently amended
The neurostimulating apparatus of claim 9, wherein the graphene bio-device is placed in somatosensory area or motor cortical area. Previously presented
A method for detecting signals from a mammalian brain or a mammalian tissue and electrical stimulation to the brain or the tissue using [[a]] the graphene SVG 16030863.12-23-2020.KJ₇KFP₂XLDFLYX3.CLM.1.svg 0.16 1.61 Black and white Currently amended
The method of claim 10, wherein the electrical stimulation is sinusoidal high frequency stimulation(s H FS). Original
12-13. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
4 materials2 process steps
Monolayer graphene was grown on 25 µm thick Cu foil by CVD at 1000°C under atmospheric pressure using a CH₄/H₂/He gas mixture. Multilayer graphene electrodes were formed by repeated PMMA-supported transfer and Cu etching in ammonium persulfate solution. The transferred graphene was patterned by photolithography and oxygen plasma etching, and chemically doped with nitric acid vapour. The electrode array was mounted onto mouse brain cortex for electrotherapy and neural recording experiments.
No measurements recorded
C₅₇BL/6 mice were anaesthetized and brain slices (400 µm) containing somatosensory cortex and thalamus were prepared. Bicuculline (1 mM) was focally injected to induce ictal-like and interictal-like spontaneous activity.
No measurements recorded
Halothane-anaesthetized mice underwent craniotomy exposing a 5×5 mm² cortical region. CSF was drained and graphene electrodes were introduced transdurally for neurophysiological recording.
1 material
Brain signals from graphene-based electronics were processed using a multichannel neural amplifier and acquisition system (Intan Technologies). Stimulations were provided by NI-9263 stimulators (National Instruments). Data were analyzed offline using Matlab.
Layer stacks claimed or described, ordered top of device to substrate.
graphene bio-device (flexible electrode array)
Materials described outside the worked examples.
insulation layer (OCR, OCA, or SU-8)
gold electrode
Au
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
specific capacitance of doped four-layer graphene electrode | 326.7 F/g | doped four-layer graphene |
specific capacitance of gold electrode (comparison) |
Table 1
2b and Table 1&2).
p. 9
Table 2
SVG
SVG 16030863.
p. 9
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,918,856Patent drawings and their descriptions. Click a drawing to enlarge it.
FIG. 1 depicts flexible graphene electrode array and treatment of epilepsy, (a) an schematic diagram of a graphene-based seizure sensor (b) an optical image of …
FIG. 2 depicts characteristics of graphene electr o des (a) E IS of doped 1-, 2-, and 4-layer graphene electr o des and a Au electr o de f o r a 1 x 1 cm 2 a r …
FIG. 3 depicts in vitro multichannel recording of neuronal activities using graphene electronics (a) A thalamocortical slice on the graphene-based multichannel …
FIG. 4 depicts in viv o multichannel re co rding and stimulation of neuronal activities using graphene electronics. (a) a schematic diagram of a recording and …
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
1-8. Canceled
Canceled
A neurostimulating apparatus, consisting of: a graphene bio-device consisting of: a flexible substrate which is PM M A(polymethyl methacrylate); doped four-layer graphene electrodes on the flexible substrat, forming an electrode array having 30 channels for recording and electrotherapy; and an insulation layer on the doped four-layer graphene electrodes, which comprise ground electrodes, reference electrodes, recording electrodes and stimulation electrodes; a neurostimulator generating sinusoidal high frequency stimulation signals and enabling the graphen bio-device to provide neurostimulating signals to a target, wherein the sinusoidal high frequency stimulation signals include an amplitude of 1V, a frequency of 100 Hz, and a duration of 30 sec; an amplifier intensifying brain signals from the graphene bio-device; and an interface transmitting the amplified brain signals to a user terminal, wherein the graphene bio-device, the neurostimulator, the amplifier, and the interface are connected to each other by a lead. Currently amended
The neurostimulating apparatus of claim 9, wherein the insulation layer is OCR(optical clean resin), OCA(optical clean adhesive) or SU-8. Previously presented
The neurostimulating apparatus of claim 9, wherein the doped four-layer graphene electrodes have a specific capacitance of 326.7 F/g. Currently amended
The neurostimulating apparatus of claim 9, wherein the graphene bio-device is placed in somatosensory area or motor cortical area. Previously presented
A method for detecting signals from a mammalian brain or a mammalian tissue and electrical stimulation to the brain or the tissue using [[a]] the graphene SVG 16030863.12-23-2020.KJ₇KFP₂XLDFLYX3.CLM.1.svg 0.16 1.61 Black and white Currently amended
The method of claim 10, wherein the electrical stimulation is sinusoidal high frequency stimulation(s H FS). Original
12-13. Canceled
Canceled
Embodiments described in the patent, grouped by the materials and process steps they use.
4 materials2 process steps
Monolayer graphene was grown on 25 µm thick Cu foil by CVD at 1000°C under atmospheric pressure using a CH₄/H₂/He gas mixture. Multilayer graphene electrodes were formed by repeated PMMA-supported transfer and Cu etching in ammonium persulfate solution. The transferred graphene was patterned by photolithography and oxygen plasma etching, and chemically doped with nitric acid vapour. The electrode array was mounted onto mouse brain cortex for electrotherapy and neural recording experiments.
No measurements recorded
C₅₇BL/6 mice were anaesthetized and brain slices (400 µm) containing somatosensory cortex and thalamus were prepared. Bicuculline (1 mM) was focally injected to induce ictal-like and interictal-like spontaneous activity.
No measurements recorded
Halothane-anaesthetized mice underwent craniotomy exposing a 5×5 mm² cortical region. CSF was drained and graphene electrodes were introduced transdurally for neurophysiological recording.
1 material
Brain signals from graphene-based electronics were processed using a multichannel neural amplifier and acquisition system (Intan Technologies). Stimulations were provided by NI-9263 stimulators (National Instruments). Data were analyzed offline using Matlab.
Layer stacks claimed or described, ordered top of device to substrate.
graphene bio-device (flexible electrode array)
Materials described outside the worked examples.
insulation layer (OCR, OCA, or SU-8)
gold electrode
Au
Measurements and analyses referenced in the patent, with their drawing references.
FIG. 5 depicts a graph of E I S of doped 1-, 2-, and 4-layer graphene electrodes.
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
specific capacitance of doped four-layer graphene electrode | 326.7 F/g | doped four-layer graphene |
specific capacitance of gold electrode (comparison) |
Table 1
2b and Table 1&2).
p. 9
Table 2
SVG
SVG 16030863.
p. 9
Related documents with shared materials, methods, properties, or citations.
SU-8 epoxy
ammonium persulfate solution
(NH₄)2S₂O₈
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
| 77.5 F/g |
Au |
optical transparency of single-layer graphene | 97.7 % | doped four-layer graphene |
Duration | 5–20 second | — |
Voltage | 1–10 V | — |
SU-8 epoxy
ammonium persulfate solution
(NH₄)2S₂O₈
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
| 77.5 F/g |
Au |
optical transparency of single-layer graphene | 97.7 % | doped four-layer graphene |
Duration | 5–20 second | — |
Voltage | 1–10 V | — |
SU-8 epoxy
ammonium persulfate solution
(NH₄)2S₂O₈
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
| 77.5 F/g |
Au |
optical transparency of single-layer graphene | 97.7 % | doped four-layer graphene |
Duration | 5–20 second | — |
Voltage | 1–10 V | — |
SU-8 epoxy
ammonium persulfate solution
(NH₄)2S₂O₈
FIG. 6 depicts a graph of frequency distribution of seizure signals (a) The seizure signals measured by doped 4-layer graphene (b) a graph of Fourier transform …
| 77.5 F/g |
Au |
optical transparency of single-layer graphene | 97.7 % | doped four-layer graphene |
Duration | 5–20 second | — |
Voltage | 1–10 V | — |