Patent
US 10,610,607MAGNETIC GRAPHENE-LIKE NANOPARTICLES OR GRAPHITIC NANO- OR MICROPARTICLES AND METHOD OF PRODUCTION AND USES THEREOF
Balaji Sitharaman
US
Copyright © 2026 Matter42. All rights reserved.
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Atlas literature
Patent
US 10,610,607Patent drawings and their descriptions. Click a drawing to enlarge it.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIGS. 3(a)-3(e). SQUID plots: Magnetization(M) v/s Field strength(H) for (a)Graphite, (b) Oxidized graphite, (c) Graphene nanoplatelets, (d) Reduced Graphene …
FIGS. 4(a)-4(c). SQUID plots: Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e (a) M vs. H at three temperatures (10, 150 and 300K) …
FIG. 5. T i -weighted MRI phantom of GONR compared with MnC 1 2 and water. [0032]
FIG. 6. Representative MR Images of a mouse before and after injection of water-soluble GNP MRI CAs at a dosage of 0.25 mmols/kg. At these low doses, 100 times …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 9(a)-9(e). -: Plot of Magnetization (M) v/s Field strength (H) for (a) micro-graphite, (b) oxidized graphite (c) Oxidized Graphene nanoplatelets (d) …
FIGS. 10(a)-10(c): Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e at 10, 150 and 300K for (a) MWCNTs, and (b) graphene nanoribbons …
FIGS. 11(a)- 1 1(d): Room temperature EPR spectra of solid (a) oxidized micro- graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 12(a)-12(d): Room temperature EPR spectra of aqueous solutions of (a) oxidized micro-graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 13(a)-13(d): Experimental NMRD profiles (dots), and best fits (solid lines) derived from SBM Theory for (a) Oxidized Graphite, (b) Graphene Nanoplatelets, …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
FIGS. 16(a)-16(b): EELS spectrum for (a) reduced graphene nanoplatelets and (b) oxidized graphene nanoplatelets showing a oxygen peak at 530 eV. [0043]
FIGS. 17(a)-17(d): EPR spectrum of the (a) Wilmad quartz EPR tubes used for the measurement of the solid samples, (b) quartz EPR flat tube used for the aqueous …
FIGS. 18(a)-18(d): Curves obtained for floating all SBM parameters to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) Reduced Graphene …
FIGS. 19(a)-19(d): Curves obtained for fixed Q=2 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 20(a)-20(d): Curves obtained for fixed Q=4 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 21(a)-21(d). Curves obtained for fixed Q=6 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 22(a)-22(d): Curves obtained for fixed Q=8 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 23(a)-23(d): Curves obtained for fixed Q=8 and Fixed T m at values shown in Table 8, with remaining SBM parameters allowed to float. A) Oxidized Graphite, …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Float all SBM parameters (Figs. 18A-18D).
Fix Q at 2, Float remaining SBM parameters (Figs. 19A-19D).
Fix Q at 4, Float remaining SBM parameters (Figs. 20A-20D).
Fix Q at 6, Float remaining SBM parameters (Figs. 21A-21D).
The composition of claim 4 7, wherein said graphene-like nanostructure is selected from the group consisting of carbon na n oplatelet and carbon nanoribbon. Previously presented
Fix Q at 8, Float remaining SBM parameters (Figs. 22A-22D).
Fix Q at 8, Fix Tm, Float remaining SBM parameters (Figs. 23(a)-23(d)).
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano-or microstructure, wherein said magnetic m etal comprises Mn, wherein the composition is configured to maintain a w ater proton relaxivity ratio of r2:r1 <4 and is configured to increase the r l relaxi vity by a factor of 2 or more as compared to Mn₂+ ion in aqueous media; and (ii) one or more physiologically acceptable carriers or excipients. Previously presented
The composition of claim 47, wherein said graphitic nano- or microstructure has a thickness of 20 pm or less. Previously presented
(Previously P resented) The magnetic composition of claim 47, wherein said graphe ne- like nanostructure comprises 2 to 12 atomic layers of carbon. Previously presented
The composition of claim 47, wherein said graphene-like nanostructure is a carbon nanoribbon having an average width in the range of 1 to 250 num ar d an average length in the range of 2 0 0 to 5000 n m. Previously presented
(Previously P resented) T he composition of claim 47, wherein said Mn is present in a Mn oxide. Previously presented
Canceled
-64. Canceled
Canceled
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano- or microstructure, wherein said magnetic metal comprises MnS 0 4; and (ii) one or more physiologically acceptable carriers or excipients. Withdrawn
Canceled
Materials described outside the worked examples.
Mn (magnetic metal)
Mn
oxidized graphene nanostructure
Measurements and analyses referenced in the patent, with their drawing references.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
water proton relaxivity ratio r2:r1 | — | Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,610,607Patent drawings and their descriptions. Click a drawing to enlarge it.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIGS. 3(a)-3(e). SQUID plots: Magnetization(M) v/s Field strength(H) for (a)Graphite, (b) Oxidized graphite, (c) Graphene nanoplatelets, (d) Reduced Graphene …
FIGS. 4(a)-4(c). SQUID plots: Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e (a) M vs. H at three temperatures (10, 150 and 300K) …
FIG. 5. T i -weighted MRI phantom of GONR compared with MnC 1 2 and water. [0032]
FIG. 6. Representative MR Images of a mouse before and after injection of water-soluble GNP MRI CAs at a dosage of 0.25 mmols/kg. At these low doses, 100 times …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 9(a)-9(e). -: Plot of Magnetization (M) v/s Field strength (H) for (a) micro-graphite, (b) oxidized graphite (c) Oxidized Graphene nanoplatelets (d) …
FIGS. 10(a)-10(c): Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e at 10, 150 and 300K for (a) MWCNTs, and (b) graphene nanoribbons …
FIGS. 11(a)- 1 1(d): Room temperature EPR spectra of solid (a) oxidized micro- graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 12(a)-12(d): Room temperature EPR spectra of aqueous solutions of (a) oxidized micro-graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 13(a)-13(d): Experimental NMRD profiles (dots), and best fits (solid lines) derived from SBM Theory for (a) Oxidized Graphite, (b) Graphene Nanoplatelets, …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
FIGS. 16(a)-16(b): EELS spectrum for (a) reduced graphene nanoplatelets and (b) oxidized graphene nanoplatelets showing a oxygen peak at 530 eV. [0043]
FIGS. 17(a)-17(d): EPR spectrum of the (a) Wilmad quartz EPR tubes used for the measurement of the solid samples, (b) quartz EPR flat tube used for the aqueous …
FIGS. 18(a)-18(d): Curves obtained for floating all SBM parameters to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) Reduced Graphene …
FIGS. 19(a)-19(d): Curves obtained for fixed Q=2 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 20(a)-20(d): Curves obtained for fixed Q=4 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 21(a)-21(d). Curves obtained for fixed Q=6 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 22(a)-22(d): Curves obtained for fixed Q=8 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 23(a)-23(d): Curves obtained for fixed Q=8 and Fixed T m at values shown in Table 8, with remaining SBM parameters allowed to float. A) Oxidized Graphite, …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Float all SBM parameters (Figs. 18A-18D).
Fix Q at 2, Float remaining SBM parameters (Figs. 19A-19D).
Fix Q at 4, Float remaining SBM parameters (Figs. 20A-20D).
Fix Q at 6, Float remaining SBM parameters (Figs. 21A-21D).
The composition of claim 4 7, wherein said graphene-like nanostructure is selected from the group consisting of carbon na n oplatelet and carbon nanoribbon. Previously presented
Fix Q at 8, Float remaining SBM parameters (Figs. 22A-22D).
Fix Q at 8, Fix Tm, Float remaining SBM parameters (Figs. 23(a)-23(d)).
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano-or microstructure, wherein said magnetic m etal comprises Mn, wherein the composition is configured to maintain a w ater proton relaxivity ratio of r2:r1 <4 and is configured to increase the r l relaxi vity by a factor of 2 or more as compared to Mn₂+ ion in aqueous media; and (ii) one or more physiologically acceptable carriers or excipients. Previously presented
The composition of claim 47, wherein said graphitic nano- or microstructure has a thickness of 20 pm or less. Previously presented
(Previously P resented) The magnetic composition of claim 47, wherein said graphe ne- like nanostructure comprises 2 to 12 atomic layers of carbon. Previously presented
The composition of claim 47, wherein said graphene-like nanostructure is a carbon nanoribbon having an average width in the range of 1 to 250 num ar d an average length in the range of 2 0 0 to 5000 n m. Previously presented
(Previously P resented) T he composition of claim 47, wherein said Mn is present in a Mn oxide. Previously presented
Canceled
-64. Canceled
Canceled
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano- or microstructure, wherein said magnetic metal comprises MnS 0 4; and (ii) one or more physiologically acceptable carriers or excipients. Withdrawn
Canceled
Materials described outside the worked examples.
Mn (magnetic metal)
Mn
oxidized graphene nanostructure
Measurements and analyses referenced in the patent, with their drawing references.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
water proton relaxivity ratio r2:r1 | — | Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,610,607Patent drawings and their descriptions. Click a drawing to enlarge it.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIGS. 3(a)-3(e). SQUID plots: Magnetization(M) v/s Field strength(H) for (a)Graphite, (b) Oxidized graphite, (c) Graphene nanoplatelets, (d) Reduced Graphene …
FIGS. 4(a)-4(c). SQUID plots: Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e (a) M vs. H at three temperatures (10, 150 and 300K) …
FIG. 5. T i -weighted MRI phantom of GONR compared with MnC 1 2 and water. [0032]
FIG. 6. Representative MR Images of a mouse before and after injection of water-soluble GNP MRI CAs at a dosage of 0.25 mmols/kg. At these low doses, 100 times …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 9(a)-9(e). -: Plot of Magnetization (M) v/s Field strength (H) for (a) micro-graphite, (b) oxidized graphite (c) Oxidized Graphene nanoplatelets (d) …
FIGS. 10(a)-10(c): Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e at 10, 150 and 300K for (a) MWCNTs, and (b) graphene nanoribbons …
FIGS. 11(a)- 1 1(d): Room temperature EPR spectra of solid (a) oxidized micro- graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 12(a)-12(d): Room temperature EPR spectra of aqueous solutions of (a) oxidized micro-graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 13(a)-13(d): Experimental NMRD profiles (dots), and best fits (solid lines) derived from SBM Theory for (a) Oxidized Graphite, (b) Graphene Nanoplatelets, …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
FIGS. 16(a)-16(b): EELS spectrum for (a) reduced graphene nanoplatelets and (b) oxidized graphene nanoplatelets showing a oxygen peak at 530 eV. [0043]
FIGS. 17(a)-17(d): EPR spectrum of the (a) Wilmad quartz EPR tubes used for the measurement of the solid samples, (b) quartz EPR flat tube used for the aqueous …
FIGS. 18(a)-18(d): Curves obtained for floating all SBM parameters to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) Reduced Graphene …
FIGS. 19(a)-19(d): Curves obtained for fixed Q=2 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 20(a)-20(d): Curves obtained for fixed Q=4 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 21(a)-21(d). Curves obtained for fixed Q=6 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 22(a)-22(d): Curves obtained for fixed Q=8 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 23(a)-23(d): Curves obtained for fixed Q=8 and Fixed T m at values shown in Table 8, with remaining SBM parameters allowed to float. A) Oxidized Graphite, …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Float all SBM parameters (Figs. 18A-18D).
Fix Q at 2, Float remaining SBM parameters (Figs. 19A-19D).
Fix Q at 4, Float remaining SBM parameters (Figs. 20A-20D).
Fix Q at 6, Float remaining SBM parameters (Figs. 21A-21D).
The composition of claim 4 7, wherein said graphene-like nanostructure is selected from the group consisting of carbon na n oplatelet and carbon nanoribbon. Previously presented
Fix Q at 8, Float remaining SBM parameters (Figs. 22A-22D).
Fix Q at 8, Fix Tm, Float remaining SBM parameters (Figs. 23(a)-23(d)).
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano-or microstructure, wherein said magnetic m etal comprises Mn, wherein the composition is configured to maintain a w ater proton relaxivity ratio of r2:r1 <4 and is configured to increase the r l relaxi vity by a factor of 2 or more as compared to Mn₂+ ion in aqueous media; and (ii) one or more physiologically acceptable carriers or excipients. Previously presented
The composition of claim 47, wherein said graphitic nano- or microstructure has a thickness of 20 pm or less. Previously presented
(Previously P resented) The magnetic composition of claim 47, wherein said graphe ne- like nanostructure comprises 2 to 12 atomic layers of carbon. Previously presented
The composition of claim 47, wherein said graphene-like nanostructure is a carbon nanoribbon having an average width in the range of 1 to 250 num ar d an average length in the range of 2 0 0 to 5000 n m. Previously presented
(Previously P resented) T he composition of claim 47, wherein said Mn is present in a Mn oxide. Previously presented
Canceled
-64. Canceled
Canceled
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano- or microstructure, wherein said magnetic metal comprises MnS 0 4; and (ii) one or more physiologically acceptable carriers or excipients. Withdrawn
Canceled
Materials described outside the worked examples.
Mn (magnetic metal)
Mn
oxidized graphene nanostructure
Measurements and analyses referenced in the patent, with their drawing references.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
water proton relaxivity ratio r2:r1 | — | Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
Related documents with shared materials, methods, properties, or citations.
Patent
Atlas literature
Patent
US 10,610,607Patent drawings and their descriptions. Click a drawing to enlarge it.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIGS. 3(a)-3(e). SQUID plots: Magnetization(M) v/s Field strength(H) for (a)Graphite, (b) Oxidized graphite, (c) Graphene nanoplatelets, (d) Reduced Graphene …
FIGS. 4(a)-4(c). SQUID plots: Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e (a) M vs. H at three temperatures (10, 150 and 300K) …
FIG. 5. T i -weighted MRI phantom of GONR compared with MnC 1 2 and water. [0032]
FIG. 6. Representative MR Images of a mouse before and after injection of water-soluble GNP MRI CAs at a dosage of 0.25 mmols/kg. At these low doses, 100 times …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 9(a)-9(e). -: Plot of Magnetization (M) v/s Field strength (H) for (a) micro-graphite, (b) oxidized graphite (c) Oxidized Graphene nanoplatelets (d) …
FIGS. 10(a)-10(c): Magnetization (M) v/s Field strength (H) between-50,000 0 e and 50,000 0 e at 10, 150 and 300K for (a) MWCNTs, and (b) graphene nanoribbons …
FIGS. 11(a)- 1 1(d): Room temperature EPR spectra of solid (a) oxidized micro- graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 12(a)-12(d): Room temperature EPR spectra of aqueous solutions of (a) oxidized micro-graphite, (b) oxidized graphene nanoplatelets, (c) reduced graphene …
FIGS. 13(a)-13(d): Experimental NMRD profiles (dots), and best fits (solid lines) derived from SBM Theory for (a) Oxidized Graphite, (b) Graphene Nanoplatelets, …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
FIGS. 16(a)-16(b): EELS spectrum for (a) reduced graphene nanoplatelets and (b) oxidized graphene nanoplatelets showing a oxygen peak at 530 eV. [0043]
FIGS. 17(a)-17(d): EPR spectrum of the (a) Wilmad quartz EPR tubes used for the measurement of the solid samples, (b) quartz EPR flat tube used for the aqueous …
FIGS. 18(a)-18(d): Curves obtained for floating all SBM parameters to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) Reduced Graphene …
FIGS. 19(a)-19(d): Curves obtained for fixed Q=2 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 20(a)-20(d): Curves obtained for fixed Q=4 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 21(a)-21(d). Curves obtained for fixed Q=6 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 22(a)-22(d): Curves obtained for fixed Q=8 with remaining SBM parameters allowed to float. A) Oxidized Graphite, B) Oxidized Graphene Nanoplatelets, C) …
FIGS. 23(a)-23(d): Curves obtained for fixed Q=8 and Fixed T m at values shown in Table 8, with remaining SBM parameters allowed to float. A) Oxidized Graphite, …
Claims define the patent's legal scope. Independent claims stand alone; dependent claims (nested) narrow them. Click a claim to expand its dependents.
Float all SBM parameters (Figs. 18A-18D).
Fix Q at 2, Float remaining SBM parameters (Figs. 19A-19D).
Fix Q at 4, Float remaining SBM parameters (Figs. 20A-20D).
Fix Q at 6, Float remaining SBM parameters (Figs. 21A-21D).
The composition of claim 4 7, wherein said graphene-like nanostructure is selected from the group consisting of carbon na n oplatelet and carbon nanoribbon. Previously presented
Fix Q at 8, Float remaining SBM parameters (Figs. 22A-22D).
Fix Q at 8, Fix Tm, Float remaining SBM parameters (Figs. 23(a)-23(d)).
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano-or microstructure, wherein said magnetic m etal comprises Mn, wherein the composition is configured to maintain a w ater proton relaxivity ratio of r2:r1 <4 and is configured to increase the r l relaxi vity by a factor of 2 or more as compared to Mn₂+ ion in aqueous media; and (ii) one or more physiologically acceptable carriers or excipients. Previously presented
The composition of claim 47, wherein said graphitic nano- or microstructure has a thickness of 20 pm or less. Previously presented
(Previously P resented) The magnetic composition of claim 47, wherein said graphe ne- like nanostructure comprises 2 to 12 atomic layers of carbon. Previously presented
The composition of claim 47, wherein said graphene-like nanostructure is a carbon nanoribbon having an average width in the range of 1 to 250 num ar d an average length in the range of 2 0 0 to 5000 n m. Previously presented
(Previously P resented) T he composition of claim 47, wherein said Mn is present in a Mn oxide. Previously presented
Canceled
-64. Canceled
Canceled
A composition for use with magnetic resonance imaging, comprising: (i) a sufficient amount of the magnetic composition comprising a magnetic metal intercalated in an oxidized graphene nanostructure or a graphitic nano- or microstructure, wherein said magnetic metal comprises MnS 0 4; and (ii) one or more physiologically acceptable carriers or excipients. Withdrawn
Canceled
Materials described outside the worked examples.
Mn (magnetic metal)
Mn
oxidized graphene nanostructure
Measurements and analyses referenced in the patent, with their drawing references.
FIGS. 1 (a)- 1 (d). TEM images at 200kV for manganese intercalated graphene nanoplatelets and nanoribbons (a) Showing ~20 nm wide few layered and multilayered …
Performance values and ranges asserted in the specification or claims.
| Property | Value | Material |
|---|---|---|
water proton relaxivity ratio r2:r1 | — | Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
Related documents with shared materials, methods, properties, or citations.
graphitic nano- or microstructure
carbon nanoplatelet
carbon nanoribbon
Mn oxide
MnSO₄
graphene nanoplatelets
graphene nanoribbons
graphite oxide
Mn₂+ ions intercalated in graphene sheets
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
r1 relaxivity increase factor vs Mn2+ in aqueous media |
| — |
Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
r1 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
r2 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
graphitic nano- or microstructure thickness | — | graphitic nano- or microstructure |
graphene-like nanostructure atomic layers of carbon | — | oxidized graphene nanostructure |
carbon nanoribbon average width | — | carbon nanoribbon |
carbon nanoribbon average length | — | carbon nanoribbon |
Temperature | 0–300 K | — |
Temperature | 10–300 K | — |
Thickness | 200–3000 cm | — |
Thickness | 2.92–9.8 mM | — |
Thickness | 1–5 nm | — |
Thickness | 0–250 mm | — |
Temperature | 55–70 °C | — |
Thickness | 40–70 nm | — |
Thickness | 500–2000 nm | — |
Thickness | 125–220 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 50–66 mM | — |
Thickness | 70–222 mM | — |
Thickness | 44–59 mM | — |
Thickness | 65–100 mM | — |
Thickness | 4–10 mM | — |
Pressure | 6313–6323 Pa | — |
Thickness | ≤ 30 nm | — |
Temperature | ≥ 300 K | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Duration | 1–3 hours | — |
Temperature | 60–95 °C | — |
Temperature | 15–80 °C | — |
graphitic nano- or microstructure
carbon nanoplatelet
carbon nanoribbon
Mn oxide
MnSO₄
graphene nanoplatelets
graphene nanoribbons
graphite oxide
Mn₂+ ions intercalated in graphene sheets
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
r1 relaxivity increase factor vs Mn2+ in aqueous media |
| — |
Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
r1 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
r2 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
graphitic nano- or microstructure thickness | — | graphitic nano- or microstructure |
graphene-like nanostructure atomic layers of carbon | — | oxidized graphene nanostructure |
carbon nanoribbon average width | — | carbon nanoribbon |
carbon nanoribbon average length | — | carbon nanoribbon |
Temperature | 0–300 K | — |
Temperature | 10–300 K | — |
Thickness | 200–3000 cm | — |
Thickness | 2.92–9.8 mM | — |
Thickness | 1–5 nm | — |
Thickness | 0–250 mm | — |
Temperature | 55–70 °C | — |
Thickness | 40–70 nm | — |
Thickness | 500–2000 nm | — |
Thickness | 125–220 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 50–66 mM | — |
Thickness | 70–222 mM | — |
Thickness | 44–59 mM | — |
Thickness | 65–100 mM | — |
Thickness | 4–10 mM | — |
Pressure | 6313–6323 Pa | — |
Thickness | ≤ 30 nm | — |
Temperature | ≥ 300 K | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Duration | 1–3 hours | — |
Temperature | 60–95 °C | — |
Temperature | 15–80 °C | — |
graphitic nano- or microstructure
carbon nanoplatelet
carbon nanoribbon
Mn oxide
MnSO₄
graphene nanoplatelets
graphene nanoribbons
graphite oxide
Mn₂+ ions intercalated in graphene sheets
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
r1 relaxivity increase factor vs Mn2+ in aqueous media |
| — |
Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
r1 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
r2 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
graphitic nano- or microstructure thickness | — | graphitic nano- or microstructure |
graphene-like nanostructure atomic layers of carbon | — | oxidized graphene nanostructure |
carbon nanoribbon average width | — | carbon nanoribbon |
carbon nanoribbon average length | — | carbon nanoribbon |
Temperature | 0–300 K | — |
Temperature | 10–300 K | — |
Thickness | 200–3000 cm | — |
Thickness | 2.92–9.8 mM | — |
Thickness | 1–5 nm | — |
Thickness | 0–250 mm | — |
Temperature | 55–70 °C | — |
Thickness | 40–70 nm | — |
Thickness | 500–2000 nm | — |
Thickness | 125–220 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 50–66 mM | — |
Thickness | 70–222 mM | — |
Thickness | 44–59 mM | — |
Thickness | 65–100 mM | — |
Thickness | 4–10 mM | — |
Pressure | 6313–6323 Pa | — |
Thickness | ≤ 30 nm | — |
Temperature | ≥ 300 K | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Duration | 1–3 hours | — |
Temperature | 60–95 °C | — |
Temperature | 15–80 °C | — |
graphitic nano- or microstructure
carbon nanoplatelet
carbon nanoribbon
Mn oxide
MnSO₄
graphene nanoplatelets
graphene nanoribbons
graphite oxide
Mn₂+ ions intercalated in graphene sheets
FIGS. 2(a)-2(b). Raman spectrum using 530nm laser (a) Revealing D and G bands and corresponding peaks for graphite, oxidized graphite, graphene nanoplatelets …
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 7. AFM section analysis of graphene nanoplatelets dispersed on a silicon substrate, showing a uniform thickness of ~1.137 nm. [0034]
FIG. 8. Comparison of Raman spectra of Hausmannite (Mn 3 O 4), oxidized graphite and reduced graphene nanoplatelets at 532nm showing spectral peaks at 657, 370 …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 14(a)-14(g): Representative SEM image of (a) oxidized micro-graphite and TEM images of (b,c) reduced graphene nanoplatelets and (d,e) graphene …
FIGS. 15(a)-15(c): Raman spectrum with the D and G bands peaks for (a) graphite, oxidized graphite, oxidized graphene nanoplatelets and reduced graphene …
r1 relaxivity increase factor vs Mn2+ in aqueous media |
| — |
Mnoxidized graphene nanostructuregraphitic nano- or microstructure |
r1 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
r2 relaxivity | — | Mn₂+ ions intercalated in graphene sheets |
graphitic nano- or microstructure thickness | — | graphitic nano- or microstructure |
graphene-like nanostructure atomic layers of carbon | — | oxidized graphene nanostructure |
carbon nanoribbon average width | — | carbon nanoribbon |
carbon nanoribbon average length | — | carbon nanoribbon |
Temperature | 0–300 K | — |
Temperature | 10–300 K | — |
Thickness | 200–3000 cm | — |
Thickness | 2.92–9.8 mM | — |
Thickness | 1–5 nm | — |
Thickness | 0–250 mm | — |
Temperature | 55–70 °C | — |
Thickness | 40–70 nm | — |
Thickness | 500–2000 nm | — |
Thickness | 125–220 nm | — |
Thickness | 600–2000 nm | — |
Thickness | 50–66 mM | — |
Thickness | 70–222 mM | — |
Thickness | 44–59 mM | — |
Thickness | 65–100 mM | — |
Thickness | 4–10 mM | — |
Pressure | 6313–6323 Pa | — |
Thickness | ≤ 30 nm | — |
Temperature | ≥ 300 K | — |
Thickness | 5–100 nm | — |
Thickness | 10–75 nm | — |
Thickness | 20–50 nm | — |
Thickness | 30–40 nm | — |
Thickness | 1–250 nm | — |
Thickness | 10–200 nm | — |
Thickness | 50–150 nm | — |
Thickness | 70–100 nm | — |
Thickness | 200–5000 nm | — |
Thickness | 400–4000 nm | — |
Thickness | 500–3000 nm | — |
Duration | 1–3 hours | — |
Temperature | 60–95 °C | — |
Temperature | 15–80 °C | — |